Plagueborn branch of Soul Tree is focused around manipulating and spreading Disease and Rot. Plagueborn also branches off into 2 more branches, Corruptive Epidemic and Withering Decay.

Plagueborn nodes allow players to apply additional debuffs when enemies are affected with Disease (Deals Disease damage for the duration), and Blood Plague (Stronger disease) and Rot (-3 walkspeed and -20 armour for the duration) debuff, which is applied from the Rotspike weapon, so getting it is a must if you plan on going with the Plagueborn.

Corruptive Epidemic sub-branch is about spreading Disease further and doing more damage. One of the more unique things about this branch is the Carrier of Corruption node, which has 20% to reanimate an enemy that dies while being inflicted with Disease, Rot or Blood Plague. The reanimated enemy will last for short duration and attack nearby enemies.

Withering Decay sub-branch on the other hand, is focused around debuffs, specifically reducing enemies mana, healing or increasing the damage the enemy takes.